Hyperostosis frontalis interna (HFI) in the population of the Dnieper-Donets archaeological culture

Abstract

Introduction. Hyperostosis frontalis interna (HFI) is a thickening of the frontal bone associated with metabolic and hormonal disorders. While prevalent among elderly women in modern populations, archaeological studies have documented male-dominated HFI cases in certain groups. This study examines the frequency of HFI in Mesolithic/Neolithic craniological series fr om the Dnieper region.

Materials and methods. Eight craniological series (107 skulls) from the collections of the Research Institute and Museum of Anthropology, Lomonosov Moscow State University, were analyzed. The overall prevalence of HFI and its developmental stages (4-point scale) were assessed.

Results and discussion. A high HFI frequency (20.6%) was identified in Mesolithic/Neolithic groups of the Dnieper region, suggesting a link to chronic metabolic stress during transitional periods. Notably, HFI types A, B, and C were equally represented (1:1:1 ratio), contrasting with typical patterns wh ere type A dominates. Elevated frequencies of types B and C likely indicate metabolic/hormonal imbalances. Although no statistically significant sex or age differences were observed, a trend of increased HFI prevalence in older individuals aligns with prior research. Associations with periodontitis, trauma, and cribra orbitalia point to environmental stress influences.

Conclusion. The identified HFI cases represent the earliest known instances in prehistoric Eastern Europe. Results underscore HFI’s role as a stress marker in transitional historical periods. © 2025. This work is licensed under a CC BY 4.0 license

References

Alekseev V.P., Debec G.F. Craniometry. Methods of Anthropological Research. Moscow: Nauka Publ., 1964. 128 p. (In Russ.).

Alexeeva T.I., Yefimova S.G., Erenbourg R.B. Craniological and osteological collections of the Institute and Museum of Anthropology, MSU. Moscow, MSU Publ., 1986, 224 p. (In Russ.).

Bodyansky A.V., Kotova N.S. Vovnyhsky 2 Late Neolithic burial ground. Archaeological Sites and History of Ancient Population of Ukraine, 1994, 1, pp. 10–15. (In Ukr.).

Buzhilova A.P. Paleopathology in bioarchaeological reconstructions. In Historical Human Ecology. Methods of Biological Research, 1998, pp. 87–147. (In Russ.).

Buzhilova A.P., Kozlovskaya M.V. Sexual dimorphism in the population and hormonal pathologies: Evidence from the Kolbino burial site. Archaeology of the Middle Don in the Scythian Era: Proceedings of the Potudan Archaeological Expedition, 2001. pp. 196–202. (In Russ.).

Buzhilova A.P., Sokolova M.A., Pererva E.V. Endocrine disorders among nomadic populations: A case study of the Sarmatian culture. OPUS: Interdisciplinary Studies in Archaeology, 2005, 4, pp. 203–216. (In Russ.).

Danilenko V.M. Voloshsky Epipaleolithic burial ground. Soviet Ethnography, 1955, 3, pp. 53–61. (In Russ.).

Kolyasnikova A.S. Anthropological aspects of variability of hyperostosis frontalis interna. PhD in Biology Thesis. Moscow, 2024. 28 p. (In Russ.).

Konduktorova T.S. Anthropology of the Mesolithic, Neolithic, and Bronze Age Populations of Ukraine. Moscow: Nauka Publ., 1973. 127 p. (In Russ.).

Pererva E.V., Moiseev V.I. Hyperostosis frontalis interna in Sarmatian skeletal remains from the Lower Volga and Don regions. Volgograd State University Bulletin, 2018, 6, pp. 18–43. (In Russ.). DOI: 10.15688/jvolsu4.2018.6.2.

Telegin D.Ya. The Dnieper-Donets Culture: On the History of the Neolithic-Early Metal Age Population of Southern Eastern Europe. Kyiv: Naukova Dumka Publ., 1968. 254 p. (In Ukr.).

Telegin D.Ya. Excavations at the Igren settlement. In Archaeological Discoveries of 1986, 1988, pp. 340–341. (In Russ.).

Telegin D.Ya., Zaliznyak L.L. Excavations on the Igren Peninsula. In Archaeological Discoveries of 1974, 1975, pp. 358–359. (In Russ.).

Bíró T.K. The late neolithic in transdanubia. Hungarian Archaeology at the Turn of the Millennium. Ministry of National Cultural Heritage -Teleki László Foundation, Budapest, 2003. 103 p.

Buzhilova A., Berezina N. Hyperostosis frontalis interna as a marker of social status? evidence from the bronze-age northern caucasus pastoralists and volga-don sarmatian nomads. 24 European Association of Archaeologists Annual Meeting. Barcelona, 2018, 1, pp. 266–266.

Devriendt W., Piercecchi-Marti M.D., Adalian P., Sanvoisin A., Dutour O. et al. Hyperostosis frontalis interna: Forensic issues. J. Forensic. Sci., 2005, 50 (1), pp. 143–146.

Gyulai F. Environment and Agriculture in Bronze Age Hungary. Archaeolingua Foundation, Budapest, 1993

Hajdu T., Fóthi E., Bernert Z., Molnár E., Lovász et al. Appearance of hyperostosis frontalis interna in some osteoarcheological series from Hungary. Homo, 2009, 60 (3), pp.185–205.

Hershkovitz I., Greenwald C., Rothschild B.M., Latimer B., Dutour O. et al. Hyperostosis frontalis interna: an anthropological perspective. Am. J. Phys. Anthropol., 1999, 109, pp. 303–325

Lazer E. Revealing secrets of a lost city: an archaeologist examines skeletal remains from the ruins of Pompeii. Med J Aust., 1996, 165, pp. 620–623.

May H., Peled N., Dar G., Abbas J., Hershkovitz I. Hyperostosis frontalis interna: what does it tell us about our health? Am. J. Hum. Biol., 2011, 23, pp. 392–397.

Mulhern D.M., Wilczak C.A., Dudar J.C. Brief communication: unusual finding at Pueblo Bonito: multiple cases of hyperostosis frontalis interna. Am. J. Phys. Anthropol., 2006, 130, pp. 480–484

Raikos A., Paraskevas G.K., Yusuf F., Kordali P., Meditskou S., et al. Etiopathogenesis of hyperostosis frontalis interna: a mystery still. Ann. Anat., 2011, 193, pp. 453–458.

Rösing F.W. Qubbet el-Hawa, Elephantine. Zur Bevölkerungsgeschichte von Ägypten. Stuttgart & New York, Fischer. 1990.

Shahin A., Alhoseiny S., Aldali M. Hyperostosis frontalis interna: An Egyptian case referred to the second dynasty (2890–2650BC) from Tarkhan-Egypt. The Egyptian Rheumatologist, 2014, 36 (1), pp. 41–45. DOI:10.1016/j.ejr.2013.08.002.

Šikanjić P. Analysis of Human Skeletal Remains from Nadin Iron Age Burial Mound. Collegium Antropologicum. 2006, 30(4), pp. 795–799.

Szeniczey T., Marcsik A., Ács Z., Balassa T., Bernert Z., et al. Hyperostosis frontalis interna in ancient populations from the Carpathian Basin - A possible relationship between lifestyle and risk of development. Int. J. Paleopathol., 2019, 24, pp. 108–118. DOI: 10.1016/j.ijpp.2018.10.003.

Watrous A.C., Anton S.C., Plourde A.M. Hyperostosis frontalis interna in ancient Egyptians. Am. J. Phys. Anthropol., 1993, 16, pp. 2–5.